Recombinant Human CD52 (C-Fc-Avi) Biotinylated

Specifications

Catalog number

PKSH033863-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD52, also known as CAMPATH-1 antigen, HE5, and gp20, is a cell surface glycoprotein that can be targeted to induce immune suppression by complement-mediated cell lysis. CD52 is expressed on lymphocytes, monocytes, monocycte-derived dendritic cells, eosinophils, and neutrophils, as well as on mature spermatozoa and epithelial cells lining the male genital tract. From the clinical point of view this protein is an important target for therapeutic interventions aimed at leukocyte depletion in hematological malignancies and post-transplant immunosuppression. CD52 / CDW52 may play a role in carrying and orienting carbohydrate. It is an unusually good target for complement-mediated cell lysis.

Abbreviation

CD52

Synonyms

CAMPATH-1; CAMPATH-1 antigen; CD52; CD52 antigen; CD52 molecule; CDw52; Epididymal secretory protein E5; HEL-S-171mP; He5; Human epididymis-specific protein 5

UniProt

P31358

Accession Number

P31358

Expression System

HEK293 Cells

Conjugation

Biotinylated

Tag

C-Fc-Avi

Sequence

Gly25-Ser36

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

30.2 kDa

Observed Molecular Weight

38-50 kDa

Species

Human