Recombinant Human Vitronectin/VTN (N-Truncated, C-6His)

Specifications

Catalog number

PKSH033866-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Vitronectin, also known as VTN, is a large glycoprotein found in blood and the extracellular matrix (ECM) . Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood coagulation, fibrinolysis, pericellular proteolysis, complement dependent immune responses, and cell attachment and spreading. Blocking of Hic (a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

Abbreviation

Vitronectin; VTN

Synonyms

Complement S-protein; S-protein; Serum Spreading Factor; Serum-spreading factor; Somatomedin B; V75; VN; VNT; VTN; Vitronectin; epibolin

UniProt

P04004

Accession Number

AAH05046.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Val62-Leu478

Field of Research

Cardiovascular, Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

48.3 kDa

Observed Molecular Weight

60-70 kDa

Species

Human