Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

Specifications

Catalog number

PKSH033872-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family) . IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9) . Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.

Abbreviation

IL-36RN; IL-1F5

Synonyms

FIL; UNQ; PRO; IL1F; IL1L; IL1HY; IL1RP; PSORS; IL36RN; FIL1; FIL1 (DELTA) ; FIL1D; IL-36Ra; IL1F5; IL1HY1; IL1L1; IL1RP3; IL36RA; PSORP; PSORS14; UNQ1896; PRO4342; FIL1 Delta; IL-1 Delta; IL-1F5; IL-1HY1; IL-1L1; IL-1ra Homolog 1; IL-1-Related Protein 3; IL-1RP3; Interleukin-1 Delta; Interleukin-1 Family Member 5; Interleukin-1 HY1; Interleukin-1 Receptor Antagonist Homolog 1; Interleukin-1-Like Protein 1; Interleukin-36 Receptor Antagonist Protein

UniProt

Q9UBH0

Accession Number

Q9UBH0

Expression System

E.coli

Tag

None

Sequence

Val2-Asp155

Applications

Cell culture

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

16.8 kDa

Observed Molecular Weight

17 kDa

Species

Human