Recombinant Human Interleukin-5/IL-5 (C-mFc)

Specifications

Catalog number

PKSH033883-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cells and eosinophils. Relative to B cells, IL-5 appears to induce the differentiation of activated conventional B-2 cells into Ig-secreting cells. In addition, it induces the growth of B-1 progenitors as well as IgM production by B-1 cells.IL-5 appears to perform a number of functions on eosinophils. These include the down modulation of Mac-1, the upregulation of receptors for IgA and IgG, the stimulation of lipid mediator (leukotriene C4 and PAF) secretion and the induction of granule release.IL-5 also promotes the growth and differentiation of eosinophils.

Abbreviation

Interleukin-5; IL-5

Synonyms

Nterleukin; Interleukin; IL5; EDF; IL-5; TRF; BCDFII; B-cell differentiation factor I; B-cell growth factor I; BCGF-II; Cytotoxic T-lymphocyte inducer; E-CSF; Eosinophil differentiation factor; ESGF; Interleukin-5; nterleukin-5; T-cell replacing factor

UniProt

P05113

Accession Number

P05113

Expression System

HEK293 Cells

Tag

C-mFc

Sequence

Ile20-Ser134

Field of Research

Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

39.8 kDa

Observed Molecular Weight

40-55 kDa

Species

Human