Recombinant Human Fas Ligand / TNFSF6 (N-6His)

Specifications

Catalog number

PKSH033886-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its ability to induce apoptosis in target cells plays an important role in the development, homeostasis, and function of the immune system. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Abbreviation

Fas Ligand; TNFSF6

Synonyms

APT1LG1CD95L; APTL; Apoptosis antigen ligand; CD178; CD178 antigen; CD95-L; CD95L; FASLCD95 ligand; FASLG; Fas Ligand; Fas antigen ligand; Fas ligand (TNF superfamily; TNFSF6; apoptosis (APO-1) antigen ligand 1; member 6)

UniProt

P48023

Accession Number

P48023

Expression System

HEK293 Cells

Tag

N-His

Sequence

Pro134-Leu281

Field of Research

Cell biology; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

17.7 kDa

Observed Molecular Weight

20-30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

Species

Human