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Product details

Recombinant Human Amyloid Precursor (C-FC)

Catalog number PKSH033887-01

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Price for PKSH033887-01

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Size / count 10 µg

Specifications

Catalog number
PKSH033887-01
Size / count
10 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Of the three major splice isoforms of APP (APP695, APP751, and APP770) APP695 is the predominant neuronal form from which Amyloid beta peptide and transcriptionally-active cleaved intracellular domain of APP (AICD) are preferentially generated by selective processing through the amyloidogenic pathway. Human APP695 consists of a 17 amino acid (aa) signal sequence, a 607 aa extracellular domain (ECD), a 24 aa transmembrane domain, and a 47 aa cytoplasmic domain. Within the ECD, human APP695 shares 97% aa sequence identity with mouse and rat APP695. Amyloid beta is a major molecule implicated in pathogenesis of Alzheimer's disease (AD) and related dementias. AICD regulates expression by direct promoter binding of multiple genes, including APP itself, the beta-secretase, BACE-1 and the Amyloid beta-degrading enzyme, Neprilysin. As such, APP695 plays an important role in brain development, learning and memory, synaptic plasticity, and neurodegeneration including AD.
Abbreviation
Amyloid Precursor
Synonyms
APP695; Amyloid Precursor; Amyloid Precursor Protein 695
UniProt
P05067
Accession Number
P05067-4
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Leu18-Lys612
Field of Research
Neuroscience
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
94.6 kDa
Observed Molecular Weight
120-145 kDa
Species
Human

Frequently Asked Questions

What is the catalog number for Recombinant Human Amyloid Precursor (C-FC)?

The catalog number for Recombinant Human Amyloid Precursor (C-FC) is PKSH033887.

What sizes are available for Recombinant Human Amyloid Precursor (C-FC)?

Recombinant Human Amyloid Precursor (C-FC) is available in the following size(s): 10 µg, 50 µg.

How many pack sizes does Recombinant Human Amyloid Precursor (C-FC) come in?

Recombinant Human Amyloid Precursor (C-FC) is available in 2 different pack sizes.

Is Recombinant Human Amyloid Precursor (C-FC) in stock?

Recombinant Human Amyloid Precursor (C-FC) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human Amyloid Precursor (C-FC)?

Recombinant Human Amyloid Precursor (C-FC) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human Amyloid Precursor (C-FC)?

Estimated delivery time for Recombinant Human Amyloid Precursor (C-FC) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human Amyloid Precursor (C-FC)?

The safety data sheet for Recombinant Human Amyloid Precursor (C-FC) is available here: https://789.bio/eb/X9q1eT.

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

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