Recombinant Human Stanniocalcin 1/STC-1 (C-6His)

Specifications

Catalog number

PKSH033893-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Stanniocalcin 1 (STC-1) is a homodimeric glycoprotein hormone that is involved in calcium and phosphate homeostasis. It was originally identified in bony fishes, where elevation of calcium in serum causes the release of STC from the endocrine glands called the corpuscles of Stannius. STC-1 inhibits the breakdown of PAPP-A, protects cancer cells from apoptosis, reduces tumor size of liver cancers, promotes osteoblast differentiation and inhibits longitudinal bone growth directly at the growth plate. It is also a biomarker of brain and lung cancer progression. STC1 signals through inhibitory G-protein modulates CGRP receptor spatial localization during osteoblastogenesis and may function as a regulatory factor interacting with calcitonin peptide members during bone formation.

Abbreviation

Stanniocalcin 1; STC-1

Synonyms

STC-1; STC1; STCSTC-1; Stanniocalcin 1; stanniocalcin-1

UniProt

P52823

Accession Number

P52823

Expression System

HEK293 Cells

Tag

C-His

Sequence

Thr18-Ala247

Field of Research

Signal Transduction; Cell biology; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

26.9 kDa

Observed Molecular Weight

28-36 kDa

Species

Human