Recombinant Human Galectin-9/LGALS9 (N-GST)

Specifications

Catalog number

PKSH033899-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galectin-9 binds galactosides and has high affinity for the Forssman pentasaccharide. Galectin-9 plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus and Inhibits cell proliferation. Galectin-9 is a ligand for HAVCR2/TIM3 and induces T-helper type 1 lymphocyte (Th1) death. In addition, Galectin-9 suppresses tumor cell metastasis by interfering with the associations CD44, VCAM-1, Integrin α4β1

Abbreviation

Galectin-9; LGALS9

Synonyms

Ecalectin; Gal-9; Gal-9delta5; Galectin-9; LGALS9; Tumor antigen HOM-HD-21

UniProt

O00182

Accession Number

O00182-2

Expression System

E.coli

Tag

N-GST

Sequence

Met1-Thr322

Field of Research

Cell Biology, Neuroscience, Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

62.2 kDa

Observed Molecular Weight

60 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 1M PBS, 100 mM GSH, 15% Glycerol, pH 8.0.

Species

Human