Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-3/HER3 (C-6His)

Specifications

Catalog number

PKSH033900-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Receptor tyrosine-protein kinase erbB-3 is an enzyme that in humans is encoded by the ERBB3 gene. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB3 belongs to the protein kinase superfamily, tyr protein kinase family and EGF receptor subfamily.It contains 1 protein kinase domain and it is expressed in Epithelial tissues and brain. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity.

Abbreviation

HER3

Synonyms

ERBB3; HER3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3

UniProt

P21860

Accession Number

P21860

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser20-Thr643

Field of Research

Signal Transduction; Cancer

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

69.5 kDa

Observed Molecular Weight

85-100 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH7.4.

Species

Human