Recombinant Human TPBG/5T4 (C-mFc)

Specifications

Catalog number

PKSH033920-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

Abbreviation

TPBG;5T4

Synonyms

5T4;5T4AG; M6P1; WAIF1

UniProt

Q13641

Accession Number

Q13641

Expression System

HEK293 Cells

Tag

C-mFc

Sequence

Ser32-Ser355

Field of Research

Cancer; Developmental Biology; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

61.7 kDa

Observed Molecular Weight

80-110 kDa

Species

Human