Recombinant Human TSLP R/CRLF2 (C-Fc)

Specifications

Catalog number

PKSH033923-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Receptor for thymic stromal lymphopoietin (TSLP) . Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity) . Implicated in the development of the hematopoietic system. TSLP R expression is ubiquitous in the immune and hematopoietic cells, but is up-regulated in Th2-skewed cells. Cells expressing TSLP R alone bind TSLP with low affinity. Co-expression of TSLP R and IL-7 R alpha is required for high-affinity TSLP binding and signal transduction . The TSLP R and IL-7 R alpha are coexpressed primarily on monocytes and dendritic cells and at lower levels in lymphoid cells. TSLP has been shown to induce the release of T cell-attracting chemokines from monocytes and enhance the maturation of CD11c+ dendritic cells.

Abbreviation

TSLP R; CRLF2

Synonyms

CRL2; CRL2cytokine receptor CRL2 precusor; CRLF2; CRLF2Y; CRLM-2; Cytokine receptor-like 2; IL-XR; ILXR; P2RY8/CRLF2 fusion; PCOR1; TSLP R; TSLP receptor; TSLPR; cytokine receptor-like factor 2

UniProt

Q9HC73

Accession Number

Q9HC73

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gly25-Lys231

Applications

BLI

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Loaded Human TSLP-His on HIS1K Biosensor, can bind Human TSLP R-Fc with an affinity constant of 37.97nM as determined in BLI assay.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

50.9 kDa

Observed Molecular Weight

60-80 kDa

Species

Human