Recombinant Human Leukocyte-associated Immunoglobulin-like Receptor 2/ LAIR2/CD306 (C-Fc)

Specifications

Catalog number

PKSH033932-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) is a secreted, 131 amino acid protein that contains one Ig-like C2 type domain, making it a member of the Ig superfamily. When compared to LAIR-1, its transmembrane counterpart, it shares 83% amino acid identity across the signal sequence and extracellular domains; although one is secreted and one is membrane-bound, the two LAIR proteins are thought to have arisen from a common gene ancestor and appear to share similar adhesion profiles. This suggests that LAIR-2 may compete with LAIR-1 for ligand binding. A 114 amino acid alternate splice form of LAIR-2 is truncated at the C terminus, but retains the entire Ig domain. The expression profile of these splice forms, and the presence of orthologs in other species, have not been reported.

Abbreviation

LAIR2; CD306

Synonyms

CD306; LAIR-2; LAIR2; Leukocyte-Associated Immunoglobulin-Like Receptor 2

UniProt

Q6ISS4

Accession Number

Q6ISS4

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln22-Pro152

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

41.0 kDa

Observed Molecular Weight

45-55 kDa

Species

Human