Recombinant Human Afamin/AFM (C-6His)

Specifications

Catalog number

PKSH033942-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Afamin also known as Alpha -Albumin is a secreted monomeric glycoprotein of the Alb/Albumin family of molecules. AFM is known to bind and transport vitamin E family molecules, playing an important role for transporting at the blood-brain-barrier. Afamin has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. AFM also serves as an osteoclast-derived chemoattractant for preosteoblasts, providing a rational for the observation that bone formation often follows bone resorption. The importance of Afamin in transport of molecules has led to a suggested diagnostic role in various diseases, including pre-eclampsia, ovarian cancer, and both gestational and type-2 diabetes.

Abbreviation

Afamin; AFM

Synonyms

AFM; ALB2; ALB2alpha-Alb; ALBA; ALBAalpha-albumin; ALF; Afamin; Alpha-Alb; Alpha-albumin

UniProt

P43652

Accession Number

P43652

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu22-Asn599

Field of Research

Signal Transduction; Cardiovascular; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

67.6 kDa

Observed Molecular Weight

80-100 kDa

Species

Human