Recombinant Human Siglec-8 (C-Fc) — image 1 of 3

Product details

Recombinant Human Siglec-8 (C-Fc)

Q: What is the catalog number for Recombinant Human Siglec-8 (C-Fc)?

The catalog number for Recombinant Human Siglec-8 (C-Fc) is PKSH033950.

Q: What sizes are available for Recombinant Human Siglec-8 (C-Fc)?

Recombinant Human Siglec-8 (C-Fc) is available in the following size(s): 10 µg, 50 µg.

Q: How many pack sizes does Recombinant Human Siglec-8 (C-Fc) come in?

Recombinant Human Siglec-8 (C-Fc) is available in 2 different pack sizes.

Q: Is Recombinant Human Siglec-8 (C-Fc) in stock?

Recombinant Human Siglec-8 (C-Fc) is currently made to order / not held in immediate stock. Contact us for lead time.

Q: Who manufactures Recombinant Human Siglec-8 (C-Fc)?

Recombinant Human Siglec-8 (C-Fc) is manufactured by Elabscience.

Q: What is the estimated delivery time for Recombinant Human Siglec-8 (C-Fc)?

Estimated delivery time for Recombinant Human Siglec-8 (C-Fc) is approximately 15 business day(s), depending on your location.

Q: Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human Siglec-8 (C-Fc)?

The safety data sheet for Recombinant Human Siglec-8 (C-Fc) is available here: https://789.bio/eb/D0yH8C.

Q: What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Q: Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.

Q: Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

Catalog number PKSH033950-01

Choose a variant (2 options)

Selecting a variant updates its price, size and availability.

Price for PKSH033950-01

Size / count 10 µg

Specifications

Catalog number: PKSH033950-01
Size / count: 10 µg
Dry ice: No
Hazardous: No
Discontinued: No
Background: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Siglec-8 is expressed on eosinophils, basophils, and mast cells, and it shows a binding preference for the carbohydrate 6-O sulfated sLex. At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 115 aa cytoplasmic domain with two tyrosine based signaling motifs. Alternative splicing generates additional isoforms that either lack most of the second Ig-like domain or have a substituted cytoplasmic domain without the signaling motifs. Cross-linking of Siglec-8 inhibits Fc epsilon RI alpha induced mast cell degranulation (9) . It also induces eosinophil apoptosis, an effect which is enhanced by the eosinophil-activating cytokines IL-5, IL-33, and GM-CSF.
Abbreviation: Siglec-8
Synonyms: CD329 antigen; CDw329; SAF-2; SAF2; SAF2SAF-2; Siglec-8; Siglec8
UniProt: Q9NYZ4
Accession Number: Q9NYZ4
Expression System: HEK293 Cells
Tag: C-Fc
Sequence: Met17-Ala363
Field of Research: Signal Transduction; immunology
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Purity: > 95 % as determined by reducing SDS-PAGE.
Bioactivity: Not validated for activity
Reconstitution: Please refer to the printed manual for detailed information.
Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight: 64.7 kDa
Observed Molecular Weight: 80-100 kDa
Species: Human

Frequently Asked Questions

What is the catalog number for Recombinant Human Siglec-8 (C-Fc)?

The catalog number for Recombinant Human Siglec-8 (C-Fc) is PKSH033950.

What sizes are available for Recombinant Human Siglec-8 (C-Fc)?

Recombinant Human Siglec-8 (C-Fc) is available in the following size(s): 10 µg, 50 µg.

How many pack sizes does Recombinant Human Siglec-8 (C-Fc) come in?

Recombinant Human Siglec-8 (C-Fc) is available in 2 different pack sizes.

Is Recombinant Human Siglec-8 (C-Fc) in stock?

Recombinant Human Siglec-8 (C-Fc) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human Siglec-8 (C-Fc)?

Recombinant Human Siglec-8 (C-Fc) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human Siglec-8 (C-Fc)?

Estimated delivery time for Recombinant Human Siglec-8 (C-Fc) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human Siglec-8 (C-Fc)?

The safety data sheet for Recombinant Human Siglec-8 (C-Fc) is available here: https://789.bio/eb/D0yH8C.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.