Recombinant Human Activin RIA/ALK-2 (C-Fc)

Specifications

Catalog number

PKSH033967-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor family. Binding of TGF-beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins. Activin RIA functions in a wide variety of growth and differentiation processes including gastrulation, skeletal system development, and cardiac morphogenesis. BMP signaling through Activin RIA is enhanced by the direct interaction between Activin RIA and RGM-B/DRAGON, a BMP coreceptor that also associates with other type I and type II receptors. Activin RIA can additionally phosphorylate the coreceptor Endoglin and is required for the inhibitory effect of Endoglin on prostate cancer cell motility.

Abbreviation

Activin RIA; ALK-2

Synonyms

ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK-2; ALK2; Activin RIA; ActivinRIA; FOP; SKR1; TSRI; activin A receptor; type I

UniProt

Q53SV1

Accession Number

Q53SV1

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Asp23-Val124

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

38.2 kDa

Observed Molecular Weight

38-45 kDa

Species

Human