Recombinant Human VEGF Receptor 2/VEGF R2/FLK-1/KDR (C-6His-Avi) Biotinylated

Specifications

Catalog number

PKSH033969-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human Vascular endothelial growth factor receptor 2 (KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs) . KDR is involved in a number of fundamental biological processes such as the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. It also plays an essential role in promoting proliferation, survival, migration and differentiation of endothelial cells, reorganization of the actin cytoskeleton. VEGFR2 is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo.The adaptor protein SHB has been shown to interact with VEGFR2 in receptor tyrosine kinase signaling. In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.

Abbreviation

VEGF R2; FLK-1; KDR

Synonyms

FLK-1; Fetal liver kinase 1; KDR; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; VEGF R2; VEGFR-2; VEGFR2; Vascular endothelial growth factor receptor 2

UniProt

P35968

Accession Number

P35968

Expression System

HEK293 Cells

Conjugation

Biotinylated

Tag

C-His-Avi

Sequence

Ala20-Glu764

Field of Research

Signal Transduction; Microbiology; Cardiovascular; Cancer; metabolism; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

86.1 kDa

Observed Molecular Weight

120-150 kDa

Species

Human