Recombinant Human LRRC32/GARP (C-Fc)

Specifications

Catalog number

PKSH033979-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

LRRC32 (Leucine-Rich Repeat Containing 32) is a Protein Coding gene. This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. LRRC32, also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T (regs) . LRRC32 is a T (reg) -specific receptor that binds latent TGF-beta and dominantly controls FOXP3 and the regulatory phenotype via a positive feedback loop. It belongs to the LRRC32/LRRC33 family and is broadly expressed in the placenta, lung, and other tissues. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. An important paralog of this gene is NRROS.

Abbreviation

LRRC32; GARP

Synonyms

D11S833E; GARP; GARPGarpin; Garpin

UniProt

Q14392

Accession Number

Q14392

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

His20-Asn627

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

92.9 kDa

Observed Molecular Weight

110 kDa

Species

Human