Recombinant Human Tumor-associated Calcium Signal Transducer 2/TROP-2 (248AA, C-6His)

Specifications

Catalog number

PKSH033991-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor associated calcium signal transducer 2 (TACSTD2, TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. Human and mouse TROP-2 share 87% amino acid (aa) similarity. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions.

Abbreviation

TROP-2

Synonyms

Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; TACSTD2; TROP2; Tumor-associated calcium signal transducer 2

UniProt

P09758

Accession Number

P09758

Expression System

HEK293 Cells

Tag

C-His

Sequence

His27-Thr274

Applications

BLI

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Loaded Anti-Human TROP-2 mAb-Fc on Protein A Biosensor, can bind Human TROP-2-His with an affinity constant of 0.21 nM as determined in BLI assay.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

28.9 kDa

Observed Molecular Weight

40-50 kDa

Species

Human