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Product details

Recombinant Human EPHA8 (C-Fc)

Catalog number PKSH034010-01

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Price for PKSH034010-01

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Size / count 10 µg

Specifications

Catalog number
PKSH034010-01
Size / count
10 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
EphA8, also known as Hek3 and Eek, is a 120 kDa glycosylated member of the Eph family of transmembrane receptor tyrosine kinases. The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference but have a common structural organization. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.
Abbreviation
EPHA8
Synonyms
EEK; EK3; EPH receptor A8; EPH- and ELK-related kinase; EPH- and ELK-related tyrosine kinase; EPH-like kinase 3; EphA8; HEK3; Hek3; ephrin type-A receptor 8
UniProt
P29322
Accession Number
P29322
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Glu31-Thr542
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
83.5 kDa
Observed Molecular Weight
90-110 kDa
Species
Human

Frequently Asked Questions

What is the catalog number for Recombinant Human EPHA8 (C-Fc)?

The catalog number for Recombinant Human EPHA8 (C-Fc) is PKSH034010.

What sizes are available for Recombinant Human EPHA8 (C-Fc)?

Recombinant Human EPHA8 (C-Fc) is available in the following size(s): 10 µg, 50 µg.

How many pack sizes does Recombinant Human EPHA8 (C-Fc) come in?

Recombinant Human EPHA8 (C-Fc) is available in 2 different pack sizes.

Is Recombinant Human EPHA8 (C-Fc) in stock?

Recombinant Human EPHA8 (C-Fc) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human EPHA8 (C-Fc)?

Recombinant Human EPHA8 (C-Fc) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human EPHA8 (C-Fc)?

Estimated delivery time for Recombinant Human EPHA8 (C-Fc) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human EPHA8 (C-Fc)?

The safety data sheet for Recombinant Human EPHA8 (C-Fc) is available here: https://789.bio/eb/bPW9OO.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

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