Recombinant Human IGF-I R/IGF1R (C-6His)

Specifications

Catalog number

PKSH034014-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues. Essentially all of the biological activities of IGF-I and II have been shown to be mediated via IGF-I R. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells, is now an attractive anti-cancer treatment target.

Abbreviation

IGF-I R; IGF1R

Synonyms

CD221; CD221 antigen; IGF-1R; IGF-I R; IGF-I receptor; IGF-IR; IGF1R; IGFIR; IGFR; JTK13; insulin-like growth factor 1 receptor

UniProt

P08069

Accession Number

P08069

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu31-Asn932

Field of Research

Signal Transduction; Cardiovascular; Neuroscience; Cancer; Developmental Biology; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

103.7&81&22.7 kDa

Observed Molecular Weight

100-130&54 kDa

Species

Human