Recombinant Human CD59 (C-6His)

Specifications

Catalog number

PKSH034028-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD59, also known as membrane attack complex inhibition factor (MACIF), Protectin, 1F5 antigen, HRF-20 and MIRL, is an approximately 20 kDa GPI anchored glycoprotein that is an important regulator of the complement system in blood. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.

Abbreviation

CD59

Synonyms

16.3A5;1F5;1F5 antigen;20 kDa homologous restriction factor; CD59; CD59 antigen; CD59 glycoprotein; EL32; FLJ38134; FLJ92039; G344; HRF-20; HRF20; MAC-IP; MACIF; MIC11; MIC11MSK21; MIN1; MIN2; MIN3; MIRL; p18-20

UniProt

P13987

Accession Number

P13987

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu26-Asn102

Field of Research

Signal Transduction; Cardiovascular; immunology; Stem cells

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

9.8 kDa

Observed Molecular Weight

15-20 kDa

Species

Human