Recombinant Human CD68/SR-D1 (C-Fc)

Specifications

Catalog number

PKSH034029-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD68, also called Scavenger Receptor D1 (SR-D1) and LAMP-4, is a heavily glycosylated type I transmembrane glycoprotein that belongs to the LAMP family. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. CD68 is also a biomarker of rheumatoid arthritis and Hodgkin's lymphoma. CD68 influences the functions of cells through NF-kB/focal adhesion kinase pathway (7) . In addition, CD68 on macrophages binds tightly to both S100A8 and S100A9 to enhance the cell immunity.

Abbreviation

CD68; SR-D1

Synonyms

CD68; CD68 antigenmacrophage antigen CD68; CD68 molecule; Macrosialin; SCARD1; SR-D1; SRD1; gp110

UniProt

P34810

Accession Number

P34810

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Asn22-Ile320

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

58.5 kDa

Observed Molecular Weight

70-100 kDa

Species

Human