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Product details

Recombinant Human Delta-like Protein 4/DLL4 (C-Fc)

Catalog number PKSH034030-01

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Price for PKSH034030-01

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Size / count 10 µg

Specifications

Catalog number
PKSH034030-01
Size / count
10 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. In mammals, four Notch homologs (Notch 1 to4) and five ligands (DLL 1, 3 and 4, Jagged 1 and 2) have been identified. DLL4 is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch 1 and Notch 4. Human and mouse DLL4 shares 86% amino acid sequence identity. Notch ligands are transmembrane proteins with a DSL motif necessary for Notch binding, tandem EGF repeats, a transmembrane region and a short intracellular domain (ICD) . Notch ligands are categorized into two subfamilies based on the presence of an extracellular cysteinerich domain and insertions that interrupt some EGF repeats in the Jagged but not the Delta ligand family. Interactions of Notch receptors with their ligands result in reciprocal regulated intramembrane proteolysis (RIP) . RIP is a mechanism for transmembrane signal transduction that involves the sequential processing by a disintegrin metalloprotease (ADAM) and then by presenilin/ γ secretase, resulting in shedding of the extracellular domains and the generation of the soluble ICD signaling fragments, respectively.
Abbreviation
Delta-like4; DLL4
Synonyms
DLL4; Delta-like protein 4; Delta4; Drosophila Delta homolog 4
UniProt
Q9NR61
Accession Number
Q9NR61
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Ser27-Pro524
Field of Research
Cell biology; Neuroscience; epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
81.2 kDa
Observed Molecular Weight
85-100 kDa
Species
Human

Frequently Asked Questions

What is the catalog number for Recombinant Human Delta-like Protein 4/DLL4 (C-Fc)?

The catalog number for Recombinant Human Delta-like Protein 4/DLL4 (C-Fc) is PKSH034030.

What sizes are available for Recombinant Human Delta-like Protein 4/DLL4 (C-Fc)?

Recombinant Human Delta-like Protein 4/DLL4 (C-Fc) is available in the following size(s): 10 µg, 50 µg.

How many pack sizes does Recombinant Human Delta-like Protein 4/DLL4 (C-Fc) come in?

Recombinant Human Delta-like Protein 4/DLL4 (C-Fc) is available in 2 different pack sizes.

Is Recombinant Human Delta-like Protein 4/DLL4 (C-Fc) in stock?

Recombinant Human Delta-like Protein 4/DLL4 (C-Fc) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Human Delta-like Protein 4/DLL4 (C-Fc)?

Recombinant Human Delta-like Protein 4/DLL4 (C-Fc) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Human Delta-like Protein 4/DLL4 (C-Fc)?

Estimated delivery time for Recombinant Human Delta-like Protein 4/DLL4 (C-Fc) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Human Delta-like Protein 4/DLL4 (C-Fc)?

The safety data sheet for Recombinant Human Delta-like Protein 4/DLL4 (C-Fc) is available here: https://789.bio/eb/y5i1iL.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

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