Recombinant Human Basigin/CD147 (C-mFc)

Specifications

Catalog number

PKSH034037-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Basigin/CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression.

Abbreviation

Basigin; CD147

Synonyms

Basic immunoglobulin superfamily; Basigin; Bsg; CD147; HT7 antigen; Membrane glycoprotein gp42

UniProt

P35613

Accession Number

P35613-2

Expression System

HEK293 Cells

Tag

C-mFc

Sequence

Ala22-His205

Field of Research

Immunology, Neuroscience, Cancer, Metabolism, Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

46.5 kDa

Observed Molecular Weight

55-65 kDa

Species

Human