Recombinant Human PVRL2/Nectin-2/CD112 (C-mIgG2a Fc)

Specifications

Catalog number

PKSH034051-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells, epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.

Abbreviation

PVRL2; Nectin-2; CD112

Synonyms

CD112; HVEB; Herpes Virus Entry Mediator B; Herpesvirus Entry Mediator B; HveB; Nectin-2; PRR2; PVRL2; Poliovirus Receptor-Related Protein 2

UniProt

Q92692

Accession Number

Q92692-2

Expression System

HEK293 Cells

Tag

C-mIgG2a Fc

Sequence

Gln32-Leu360

Field of Research

Immunology, Microbiology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

62.6 kDa

Observed Molecular Weight

80-90 kDa

Species

Human