Recombinant Human ILDR2 (C-6His)

Specifications

Catalog number

PKSH034056-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasis. The human ILDR2 lumenal domain shares a 99% and 98% homology with the mouse and rat respectively. The human gene encoding ILDR2 is located in a region on Chr1q23–25 that has been associated with type 2 diabetes. ILDR2 plays critical roles in hepatic clearance of lipoproteins and in lipid homeostasis. ILDR2 regulates human dendritic cells (DC2 cells, a subpopulation of polarized DCs that promotes Th2 differentiation) . Recent publications reported that ILDR2 displayed negative regulatory functions on human and mouse T cells in various experimental systems. Fusion protein of ILDR2 lumenal domain with an Fc fragment, displays therapeutic effects in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA) . ILDR2 represents a novel B7-like ligand that exerts negative immune modulation via interaction with a putative counterpart receptor expressed on activated T cells.

Abbreviation

ILDR2

Synonyms

Immunoglobulin-like domain containing receptor; Ildr; Dbsm; C1orf; DJ782G; Angulin; Angulin-3; Dbsm1; DJ782G3.1; immunoglobulin-like domain containing receptor 2; LISCH-Like; C1orf32; ILDR2

UniProt

Q71H61

Accession Number

Q71H61

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu21-Glu186

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

19.5 kDa

Observed Molecular Weight

45-55 kDa

Species

Human