Recombinant Human IL-23 p19 protein (His Tag)

Specifications

Catalog number

PKSH034108-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.

Abbreviation

IL-23 p19

Synonyms

UNQ; PRO; IL-23; IL-23A; IL23A; SGRF; UNQ2498; PRO5798

UniProt

Q9NPF7

Accession Number

Q9NPF7

Expression System

E.coli

Tag

N-His

Sequence

Arg 20-Pro 189

Applications

Cell culture

Field of Research

Immunology, Microbiology, Cancer

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

19.5 kDa

Observed Molecular Weight

17 kDa

Species

Human