Recombinant Human IL-24 protein (His Tag)

Specifications

Catalog number

PKSH034109-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I intereferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2.

Abbreviation

IL-24

Synonyms

MDA; MOB; Melanoma Differentiation Association Protein; IL24; C49A; FISP; IL10B; MDA7; MOB5; ST16; MDA-7 (Melanoma Differentiation-Associated gene 7 protein) ; Melanoma Differentiation Association Protein 7; IL 24; IL 4 induced secreted protein; IL-24; interleukin 24; Interleukin-24; MDA-7; Melanocyte associated Mda 7; Melanoma differentiation-associated gene 7 protein; Suppression of tumorigenicity 16; Suppression of tumorigenicity 16 (melanoma differentiation) ; Suppression of tumorigenicity 16 protein

UniProt

Q13007

Accession Number

Q13007

Expression System

E.coli

Tag

C-His

Sequence

Gln 52-Leu 206

Applications

Cell culture

Field of Research

Immunology, Cancer

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

19.1 kDa

Observed Molecular Weight

17 kDa

Species

Human