Recombinant Human IL-29 protein (His Tag)

Specifications

Catalog number

PKSH034114-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Abbreviation

IL-29

Synonyms

IFN-lambda; Interleukin; ytokine Zcyto; Cytokine Zcyto; IFNL; ZCYTO; IFN-λ; lambda; Cytokine Zcyto21; IFN-lambda-1; IFN-λ1; IL-29; interferon; interferon lambda 1; Interferon lambda-1; Interleukin-29; lambda 1; ytokine Zcyto21; IL29; ZCYTO21; IFNL1

UniProt

Q8IU54

Accession Number

Q8IU54

Expression System

E.coli

Tag

C-His

Sequence

Pro 23-Thr 200

Applications

Cell culture

Field of Research

Immunology, Microbiology

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

20.7 kDa

Observed Molecular Weight

22 kDa

Species

Human