Recombinant Human IL-30 protein (N-His)

Specifications

Catalog number

PKSH034115-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

IL-30, also known as IL-27A, p28. IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a heterodimeric cytokine complex, and associates with another subunit EBI3 (EBV-induced gene 3), and IL-12 p40-related protein (IL-27B) . IL-27 protein is an early product of activated antigen-presenting cells and drives the rapid clonal expansion of naive CD4 (+) T cells and plays a role in the early regulation of Th1 cells initiation which drives efficient adaptive immune response. IL-27 protein has an antiproliferative activity on melanomas through WSX-1/STAT1 signaling. Thus, IL-27 protein may be an attractive candidate as an antitumor agent applicable to cancer immunotherapy.

Abbreviation

IL-30

Synonyms

MGC; IL27p; IL27; IL-27; IL-27A; IL27A; IL27p28; IL30; p28; IL-27-p28 subunit; MGC71873; p28; IL-27B

UniProt

Q8NEV9

Accession Number

Q8NEV9

Expression System

E.coli

Tag

C-His

Sequence

Phe 29-Pro 243

Field of Research

Immunology, Cancer

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

25.5 kDa

Observed Molecular Weight

28 kDa

Species

Human