Recombinant Human BMP-6 protein (His Tag)

Specifications

Catalog number

PKSH034132-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of hepcidin/HAMP expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression.

Abbreviation

BMP-6

Synonyms

VG-1-related protein; VGR

UniProt

P22004

Accession Number

P22004

Expression System

E.coli

Tag

C-His

Sequence

Val 397-His 513

Applications

Cell culture

Field of Research

Signal Transduction, Cell Biology, Stem Cells

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.1 kDa

Observed Molecular Weight

13 kDa

Species

Human