Recombinant Mouse TSLP Protein (His Tag)

Specifications

Catalog number

PKSM040390-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7) -like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs) . Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation. Subsequent studies have shown that TSLP promotes T helper type 2 (TH2) cell responses associated with immunity to some helminth parasites and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. TSLP can promote TH2 cytokine-associated inflammation by directly promoting the effector functions of CD4+ TH2 cells, basophils and other granulocyte populations while simultaneously limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues.

Synonyms

TSLP; Thymic stroma-derived lymphopoietin; Thymic stromal lymphopoietin; Tslp

UniProt

Q9JIE6

Accession Number

Q9JIE6

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met 1-Glu 140

Applications

ELISA

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Measured by its ability to bind human IL7RA-his in functional ELISA.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

15.4 kDa

Observed Molecular Weight

22-27 kDa

Species

Mouse