Recombinant Mouse KYNU/Kynureninase Protein (His Tag)

Specifications

Catalog number

PKSM040748

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Genetic studies in mouse and human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension was previously detected in the Chinese Han population.The results show that the rare KYNU variant Arg188Gln affects kynureninase activity and are consistent with the hypothesis that this mutation can predispose to essential hypertension.

Synonyms

4432411A05Rik

UniProt

Q9CXF0

Accession Number

Q9CXF0

Expression System

Baculovirus-Insect Cells

Tag

C-His

Sequence

Met 1-Ser 464

Applications

Enzyme

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 94 % as determined by reducing SDS-PAGE.

Bioactivity

Measured by its ability to oxidize 3-hydroxykynurenine. The specific activity is > 100 pmoles/min/μg.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

53.7 kDa

Observed Molecular Weight

47 kDa

Species

Mouse