Recombinant Mouse ALCAM/CD166 Protein (Fc Tag)

Specifications

Catalog number

PKSM040954-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activated leukocyte cell adhesion molecule (ALCAM), also named as CD166 and MEMD, is a typeI transmembrane glycoprotein of immunoglobulin superfamily, which mediates homotypic and heterotypic interactions between cells. ALCAM interacts with high affinity with CD6 molecule but weaker homotypic (ALCAM–ALCAM) interactions have also been described. ALCAM–CD6 interactions play an important role in the maintenance of T cell activation, proliferation as well as in formation of immune synapse between antigen-presenting cell and lymphocytes. ALCAM is expressed on a wide variety of cells, particularly on activated lymphocytes, dendritic cells and monocytes, and on various epithelial cell types. It is also involved in multiple processes including embryogenesis, hematopoiesis, angiogenesis, and immune response. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells in most adult tissues. Recently studies showed ALCAM has prognostic relevance in several human carcinomas, and it has been used as a biomarker for several tumor entities, including melanoma, gynecologic, urologic, and gastrointestinal cancers.

Abbreviation

ALCAM; CD166

Synonyms

AI853494; BEN; CD166; CD166 antigen; CD6 ligand; CD6L; DM-GRASP; MEMD; MuSC; Protein DM-GRASP; SC1; activated leucocyte cell adhesion molecule; cluster of differentiation 166

Accession Number

Q61490

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Trp28-Lys527

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

84.2 kDa

Observed Molecular Weight

100-120 kDa

Species

Mouse