Recombinant Mouse HVEM/TNFRSF14 Protein (Fc Tag)

Specifications

Catalog number

PKSM040955-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. It has demonstrated that HVEM Ig is able to exert a significant antiviral effect against HSV-1 infection in vivo.

Abbreviation

HVEM; TNFRSF14

Synonyms

ATAR; Atar; HVEM; Herpesvirus entry mediator; HveA; TNF receptor-like molecule; TR2; Tnfrsf14; Tumor necrosis factor receptor superfamily member 14; another TRAF-associated receptor

Accession Number

Q80WM9

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln39-Val207

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

455 kDa

Observed Molecular Weight

50-60 kDa

Species

Mouse