Recombinant Mouse ALK4/ACVR1B Protein (Fc Tag)

Specifications

Catalog number

PKSM040959-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activin Receptor Type-1B (ACVR1B) is a single-pass type I membrane protein that belongs to the protein kinase superfamily. ACVR1B contains one GS domain and one protein kinase domain and is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B, ACVR2A or ACVR2B activating ACVR1B through phosphorylation of its regulatory GS domain. They go on to recruit the R-SMADs, SMAD2 and SMAD3. ACVR1B also transducers signals of nodal, GDF-1, and Vg1. Mutations in ACVR1B are associated with pituitary tumors.

Abbreviation

ALK4; ACVR1B

Synonyms

ACTR-IB; ACVR1B; ACVRLK4; ALK-4; ALK4; Activin Receptor Type IB; Activin Receptor Type-1B; Activin Receptor-Like Kinase 4; SKR2; Serine/Threonine-Protein Kinase Receptor R2

UniProt

Q61271

Accession Number

Q61271

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Leu32-Glu126

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

37.7 kDa

Observed Molecular Weight

39-50 kDa

Species

Mouse