Recombinant Mouse Adiponectin/AdipoQ Protein (E.coli, His Tag)

Specifications

Catalog number

PKSM040960-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Adiponectin is a secreted protein. It is synthesized exclusively by adipocytes and secreted into plasma. Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin Stimulates AMPK phosphorylation and activates in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Adiponectin also antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex: LMW, MMW or HMW.

Abbreviation

Adiponectin; AdipoQ

Synonyms

30 kDa Adipocyte Complement-Related Protein; ACRP30; ADIPOQ; Adipocyte; Adipocyte complement-related 30 kDa protein; Adiponectin; Adipose Most Abundant Gene Transcript 1 Protein; C1q and Collagen Domain-Containing Protein; Gelatin-Binding Protein; apM-1

UniProt

Q60994

Accession Number

Q60994

Expression System

E.coli

Tag

N-His

Sequence

Glu18-Asn247

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

27.2 kDa

Observed Molecular Weight

30 kDa

Species

Mouse