Recombinant Mouse Carbonic Anhydrase XII/CA12 Protein (His Tag)

Specifications

Catalog number

PKSM040971-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Carbonic Anhydrase (CA) XII, also known as Car12 and CA12, is an extracellular enzyme involved in the regulation of the microenvironment acidity and tumor malignant phenotype, was originally identified as a protein overexpressed in some types of cancers. It has showed that CA XII is induced by hypoxia and oestrogen and expressed at high levels on various types of cancer. The enzyme is directly involved in tumour progression, and its inhibition has an anti-tumour effect. Apart from its role in carcinogenesis, the enzyme contributes to various other diseases like glaucoma and arteriosclerotic plaques, among others. CA XII is therefore regarded as promising target for specific therapies, and may be used as a novel prognostic marker in combination with histologic grade of the tumors.

Abbreviation

Carbonic Anhydrase XII; CA12

Synonyms

CA-XII; CA12; CAXII; Car12; Carbonate dehydratase XII; Carbonic anhydrase 12; Carbonic anhydrase XII

UniProt

Q8CI85

Accession Number

Q8CI85

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala25-Ser301

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

32.4 kDa

Observed Molecular Weight

35-40 kDa

Species

Mouse