Recombinant Mouse Carbonic Anhydrase 4/CA4 Protein (aa 18-277, His Tag)

Specifications

Catalog number

PKSM040973-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Carbonic anhydrase 4 (CA4) is an enzyme that belongs to the alpha-carbonic anhydrase family. CA4 consists of a signal peptide (residues1-17), an ectodomain (residues18-277) and a propeptide (residues278-305), which is removed in the mature form. it is predominantly expressed in the embryo. CA4 can catalyzes the reversible reaction of CO2+H2O=HCO3-+H+, and stimulates the sodium/bicarbonate transporter activity of SLC4A4. Studies have shown that this protein have a role in inherited renal abnormalities of bicarbonate transport. Alpha-carbonic anhydrase family participate in avariety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor. They show extensive diversity in tissue is attribution and in their sub cellular localization.

Abbreviation

Carbonic Anhydrase 4; CA4

Synonyms

CA-IV; CA4; CAIV; Car4; Carbonate dehydratase IV; EC4.2.1.1; RP17; carbonic anhydrase 4; carbonic anhydrase IVRP17; carbonic dehydratase IV; retinitis pigmentosa 17

UniProt

Q64444

Accession Number

Q64444

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu18-Ser277

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

30.5 kDa

Observed Molecular Weight

36 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.

Species

Mouse