Recombinant Mouse CCL21a Protein

Specifications

Catalog number

PKSM040980-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

C-C Motif Chemokine 21a (CCL21a) is a small secreted cytokine that belongs to the intercrine beta (CC chemokine) family. Mouse CCL21 cDNA encodes a 133 amino acid residue protein with a 23 residue signal peptide that is cleaved to generate the 110 residue mature protein. Mouse CCL21 has three forms while CCL21a has Ser-65. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7 and CXCR3. Mouse CCL21 inhibits hemopoiesis and stimulates chemotaxis. It has chemotactic function in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Mouse CCL21 shows preferential activity towards naive T-cells and may play a role in mediating homing of lymphocytes to secondary lymphoid organs.

Abbreviation

CCL21a

Synonyms

6Ckine; Beta-Chemokine Exodus-2; C-C Motif Chemokine 21a; Ccl21a; Scya21; Scya21a; Small-Inducible Cytokine A21a; TCA4; Thymus-Derived Chemotactic Agent 4

UniProt

P84444

Accession Number

P84444

Expression System

E.coli

Tag

None

Sequence

Ser24-Gly133

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

12.0 kDa

Observed Molecular Weight

16 kDa

Species

Mouse