Recombinant Mouse CXCL1 Protein (His Tag)

Specifications

Catalog number

PKSM040992-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Growth-regulated alpha protein (CXCL1, KC), is a member of the alpha chemokine subfamily, was initially identified as an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor. The N-terminal processed form KC (5-72) of the protein is produced by proteolytic cleavage after secretion from bone marrow stromal cells, and shows a highly enhanced hematopoietic activity. Mouse KC shows approximately 63% identity to that of mouse MIP-2. KC is also approximately 60% identical to the human GROs. It has been suggested that mouse KC and MIP-2 are the orthologs of the human GROs and rat CINCs. Cxcl1 has chemotactic activity for neutrophils, and contributes to neutrophil activation during inflammation. Hematoregulatory chemokine, in vitro, suppresses hematopoietic progenitor cell proliferation.

Abbreviation

CXCL1

Synonyms

C-X-C motif chemokine 1; Cxcl1; Gro; Gro1; Growth-regulated alpha protein; Mgsa; Platelet-derived growth factor-inducible protein KC; Scyb1; Secretory protein N51

UniProt

P12850

Accession Number

P12850

Expression System

HEK293 Cells

Tag

C-His

Sequence

Arg20-Lys96

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

9.4 kDa

Observed Molecular Weight

11—13 kDa

Species

Mouse