Recombinant Mouse CXCL2/MIP-2 Protein

Specifications

Catalog number

PKSM040996-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

C-X-C motif chemokine 2 (CXCL2, MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs. Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.

Abbreviation

CXCL2; MIP-2

Synonyms

C-X-C motif chemokine 2; GRO beta; GRO2; GROB; Gro-beta; Growth-regulated protein beta; MGSA-b; MGSA-beta; MIP-2; MIP2-alpha; MIP2A; Macrophage Inflammatory Protein-2-alpha; SCYB2.; chemokine ligand 2; cxcl2; melanoma growth stimulatory activity beta

UniProt

P10889

Accession Number

P10889

Expression System

E.coli

Tag

N-His

Sequence

Ala28-Asn100

Applications

Cell culture

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

8.7 kDa

Observed Molecular Weight

11 kDa

Species

Mouse