Recombinant Mouse CXCL9 Protein

Specifications

Catalog number

PKSM040997-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), is a small cytokine belonging to the CXC chemokine family. CXCL9 functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. It together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour endothelial cells secrete high levels of CXCL9 in all, and CXCL10 in most melanoma metastases. it plays an important role in CD4+ T lymphocyte recruitment and development of CAV, MOMA-2+ macrophages are the predominant recipient-derived source of CXCL9, and recipient CD4 lymphocytes are necessary for sustained CXCL9 production and CAV development in this model.

Abbreviation

CXCL9

Synonyms

C-X-C motif chemokine 9; Cxcl9; Gamma-interferon-induced monokine; MIG; Monokine induced by interferon-gamma; Scyb9; Small-inducible cytokine B9

UniProt

P18340

Accession Number

AAA39706.1

Expression System

E.coli

Tag

N-His

Sequence

Thr22-Thr126

Applications

Cell culture

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

50

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

13.0 kDa

Observed Molecular Weight

11-17 kDa

Species

Mouse