Recombinant Mouse Granzyme B (G, H) /GZMB Protein (His Tag)

Specifications

Catalog number

PKSM041035-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Granzyme B (GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Abbreviation

Granzyme B; GZMB

Synonyms

CCP1; CTLA-1; Ctla-1; Ctla1; Cytotoxic cell protease 1; Fragmentin-2; Granzyme B (G, H) ; Gzmb

UniProt

P04187

Accession Number

P04187

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gly19-Ser247

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

26.5 kDa

Observed Molecular Weight

35 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

Species

Mouse