Recombinant Mouse CD74 Protein (mFc & His Tag)

Specifications

Catalog number

PKSM041039-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mouse HLA class II histocompatibility antigen gamma chain (CD74), is a single-pass type II membrane protein that in humans is encoded by the CD74 gene. It contains 1 thyroglobulin type-1 domain. CD74 Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

Abbreviation

CD74

Synonyms

CD74 antigen; CD74 molecule; Cluster of Differentiation 74; DHLAG gamma chain of class II antigens; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; HLADG; class II invariant chain; major histocompatibility complex

UniProt

P04441

Accession Number

P04441-2

Expression System

HEK293 Cells

Tag

C-mFc-His

Sequence

Gln56-Leu215

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

44.5 kDa

Observed Molecular Weight

45-55 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.5.

Species

Mouse