Recombinant Mouse IGFBP6/IGFBP-6 Protein (His Tag)

Specifications

Catalog number

PKSM041045-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Insulin-like growth factors (IGFs) comprise a family of endocrine, paracrine and autocrine polypeptides consisting of the ligands IGF1 and IGF2, two receptors (IGF1R, IGF2R), at least 6 IGF-binding proteins (IGFBPs) and IGFBP proteases. Among the binding proteins, IGFBP6 is unique because of its N-terminal disulfide linkages and its marked binding preference for IGF2. It is a potent inhibitor of the interaction between IGF2 and its receptor IGF1R, thus preventing major functions of IGF2, such as induction of proliferation, differentiation, cell adhesion, or colony formation. In particular, IGFBP-6 inhibited the growth of neuroblastoma and rhabdomyosarcoma xenografts. GFBP-6 is expressed in many tissues, including lung, liver, gut and the central nervous system.

Abbreviation

IGFBP6; IGFBP-6

Synonyms

IBP-6; IBP6; IGF binding protein 6; IGF-binding protein 6; IGFBP-6; Igfbp6; Insulin-like growth factor-binding protein 6; insulin-like growth factor-binding protein 6

UniProt

P47880

Accession Number

P47880

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala26-Gly238

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

23.7 kDa

Observed Molecular Weight

28 kDa

Species

Mouse