Recombinant Mouse IL1R1/CD121a Protein (Fc Tag)

Specifications

Catalog number

PKSM041047-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mouse Interleukin-1 receptor type 1/IL-1 RI is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA) . It is an important mediator involved in many cytokine induced immune and inflammatory responses. An IL1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL1α or IL1βbut not IL1ra, was identified. This Type I receptor complex appears to mediate all the known IL1 biological responses. The receptor Type II has a short cytoplasmic domain and does not transduce IL1 signals. In addition to the membranebound form of IL1 RII, a naturallyoccurring soluble form of IL1 RII has been described. It has been suggested that the Type II receptor, either as the membranebound or as the soluble form, serves as a decoy for IL1 and inhibits IL1 action by blocking the binding of IL1 to the signaling Type I receptor complex.

Abbreviation

IL1R1; CD121a

Synonyms

D2S; Interleukin-1 receptor type; IL1-R; mIL-1R; CD121 antigen-like family member A; CD121a; CD121b; D2S1473; IL-1 RI; IL1R; Il1r-1; IL1-R1; IL-1R-1; IL-1R-alpha; IL-1RT1; IL-1RT-1; IL-iR; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; mIL-1R1; P80; Il-1r1; Il1ra; Il1r1; IL-1R type I; IL1R; Interleukin 1 receptor; interleukin 1 receptor type 1; mIL-1R1; type I

UniProt

P13504

Accession Number

P13504

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Leu20-Lys338

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

64.0 kDa

Observed Molecular Weight

85-110 kDa

Species

Mouse