Recombinant Mouse IL1R2/CD121b Protein (Fc Tag)

Specifications

Catalog number

PKSM041049-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mouse Interleukin 1 receptor, type II (IL1R2) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. IL-1R2 structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain. It is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Mouse IL1RII shares 59% amino acid sequence homology with human IL1 RII in their extracellular domains. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB) . IL1R1 contributes to IL-1 signaling, whereas the IL-1R2 has no signaling property and acts as a decoy for IL-1.

Abbreviation

IL1R2; CD121b

Synonyms

Interleukin-1 receptor type; CD121 antigen-like family member B; CD121b; IL-1 type II receptor; Il1r-2; IL-1R-2; IL-1R-beta; IL-1RT2; IL-1RT-2; Interleukin-1 receptor beta; Interleukin-1 receptor type 2; Interleukin-1 receptor type II; Il-1r2; Il1rb; Il1r2; IL-1R type II; CDw121b; CDw121b; IL1R2c; Interleukin 1 receptor; interleukin 1 receptor type 2; type II

UniProt

P27931

Accession Number

P27931

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Phe14-Glu355

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 80 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

64.9 kDa

Observed Molecular Weight

85-110 kDa

Species

Mouse