Recombinant Mouse IL1RL1/ST2 Protein (His Tag)

Specifications

Catalog number

PKSM041050-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2) . ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.

Abbreviation

IL1RL1; ST2

Synonyms

STE; DER; Fit; Protein T; Protein ST; Lymphocyte antigen; Interleukin-1 receptor-like; suppression of tumorigenicity; IL1RL; IL-1 R; IL-1RL; DER4; Fit-1; IL-1 R4; IL-1RL1; IL-33R; Interleukin-1 receptor-like 1; Lymphocyte antigen 84; Protein ST2; Protein T1; ST2L; ST2V; suppression of tumorigenicity 2; Ly84; St2; Ste2; Il1rl1

UniProt

P14719

Accession Number

P14719-2

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser27-Ala337

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

36.6 kDa

Observed Molecular Weight

55-70 kDa

Species

Mouse