Recombinant Mouse IFNGR1 Protein (His Tag)

Specifications

Catalog number

PKSM041060-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The tetrameric receptor complex for IFNγ consists of two subunits, IFNGR1 (IFNγ Rα) and IFNGR2 (IFNγ Rβ), through which the dimeric IFN-γ exerts its biological functions, including antiviral, antiproliferation and immune-modulatory activity in mammals. Both IFNGR1 and IFNGR2 are single transmembrane proteins belonging to the class II cytokine family. FNGR1, widely expressed in most host cells, is essential for IFNγ binding, receptor trafficking, and signal transduction. IFNGR1 possesses an intracellular Janus tyrosine kinase (JAK) 1 binding site, a signal transducer and activator of transcription 1 (STAT1) binding site. The resulting STAT1 homodimers translocate from the cytoplasm to the nucleus and bind to the interferon-gamma activated sequence (GAS) promoter to induce expression of downstream interferon stimulated genes (ISGs) .

Abbreviation

IFNGR1

Synonyms

CD119; CD119 antigen; IFN gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; IFNGR; IFNGR1; Interferon gamma receptor 1; immune interferon receptor 1; interferon gamma receptor 1; interferon-gamma receptor alpha chain

UniProt

P15261

Accession Number

P15261

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala26-Asp253

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

26.9 kDa

Observed Molecular Weight

38-55 kDa

Species

Mouse